Overview
Mightex offers a variety of calcium imaging solutions ranging from LED light sources and cameras to full all-optical imaging and optogenetics systems.
Key System Requirements
- Quick and easy integration with existing experimental rigs/setups
- High temporal resolution for reliable and accurate GCaMP(GECI) data acquisition
- Ability to cover a variety of FOVs
- Ability to excite multiple sensors (multi-color)
- Reconfigurable to include optogenetic stimulation
LED Light Sources and Cameras
Mightex offers a variety of calcium imaging solutions ranging from LED light sources and cameras to full all-optical imaging and optogenetics systems. Please contact our applications specialists to discuss your needs and find out more about our options.
For more details, please click here➡️
Research Highlights using Microscopy LEDs
During larval development in Drosophila, researchers investigated synaptic growth and connectivity in the nociceptive network. They found that the connectivity between primary nociceptors and downstream neurons scales with the animal’s size. The study identified the Ste20-like kinase Tao as a negative regulator of synaptic growth, crucial for maintaining circuit specificity and functional output of the neuronal network during animal growth.
For more details, please click here!
Federico Marcello Tenedini & Peter Soba
University Medical Center, Hamburg, Germany
Research Highlights using Microscopy LEDs
Maintenance of cell type-specific connectivity and circuit function requires Tao kinase (Nature Communications 2022).
During larval development in Drosophila, researchers investigated synaptic growth and connectivity in the nociceptive network. They found that the connectivity between primary nociceptors and downstream neurons scales with the animal’s size. The study identified the Ste20-like kinase Tao as a negative regulator of synaptic growth, crucial for maintaining circuit specificity and functional output of the neuronal network during animal growth.
For more details, please click here!
Federico Marcello Tenedini & Peter Soba
University Medical Center, Hamburg, Germany
Research Highlights using Microscopy LEDs
During larval development in Drosophila, researchers investigated synaptic growth and connectivity in the nociceptive network. They found that the connectivity between primary nociceptors and downstream neurons scales with the animal’s size. The study identified the Ste20-like kinase Tao as a negative regulator of synaptic growth, crucial for maintaining circuit specificity and functional output of the neuronal network during animal growth.
For more details, please click here!
Federico Marcello Tenedini & Peter Soba
University Medical Center, Hamburg, Germany
Neuroscience 2017).
In Parkinson’s disease, α-synuclein overexpression (ASOX) induces toxic aggregates in vulnerable neurons. While ASOX causes hyperactivity in substantia nigra dopamine neurons, using wide-field somatic calcium imaging, researchers found that DMV neurons maintain normal firing rates through a homeostatic response involving reduced oxidative stress and downregulation of calcium channels.
Efrat Lasser-Katz & Joshua A. Goldberg
The Hebrew University of Jerusalem, Jerusalem, Israel
