Microscopy LEDs

Mightex BLS-series BioLED light sources are modularized fully-customizable turn-key solutions for optogenetics, fluorescence excitation, and other biophotonics applications. Precisely-timed and high-intensity light pulses are required in optogenetics experiments to activate channelrhodopsins (ChR2, ChR1 etc.) and halorhodopsins (NpHR) in order to excite and inhibit neurons. To meet these requirements, Mightex has developed a proprietary “IntelliPulsing” technology to allow BLS-series sources to output significantly higher power in pulse mode than what the LEDs are rated for in CW mode.

Features:

  • High-power UV/VIS/NIR/white fiber-coupled LED’s
  • Interchangeable fiber with SMA connector
  • No moving parts in optical path
  • Multiple mounting features for lab and OEM applications
  • Optional LED controllers
  • Compact, machined metal housing with integrated heat sink
  • Locking electrical connector
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Selecting a Microscopy LED Light Source

1. Select LED Wavelength

led wavelengths

2. Select LED Configuration

Single-Wavelength

Type A, Type B, Type J & Type H

Multi-Wavelength

Type A, Type B, Type J & Type H

Wavelength-Switchable

Type A

3. Select LED Controller

Manual/Analog

BLS-1000-2, BLS-3000-2, BLS-13000-1, and BLS-18000-1

bls-1000-2_3

Manual/Software/Analog/TTL

Add a BLS-IO04-US

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4. Microscope Coupling

Microscope adapters are available for all major manufacturers (Nikon, Olympus, Leica, Zeiss). If you have a different microscope, please contact us.

Direct-Coupling

wheelled on a microscope

Lightguide-Wavelength

wheelled lightguide option

Microscopy LED Application Examples

Abdelfattah et al., developed novel chemigenetic indicators for in vivo voltage imaging in neurons. To illuminate their indicators, the group used Mightex’s Microscope LEDs.

In this work, Crandall et al., used Mightex’s Microscope LEDs to optically stimulating different neuronal pathways connecting to pyramidal neurons found in L6 of the whisker somatosensory cortex of mice.

To study phase resetting curves in vivo, Higgs and Wilson used Mightex’s Microscope LEDs to establish whether their novel method of optogenetic barrage stimulation would work during extracellular spike recordings (a recording method often used in in vivo experiments).