In multi-threaded, event-driven experiments including in freely-behaving neuroscience animal research, there is a need for the data-acquisition system to react to different triggering events with different user-defined responses, in which cameras, light sources, or other devices are activated in a pre-programmed fashion. In such experiments, triggering events usually do not occur in a predefined sequence but rather in a largely random manner. Multiple hardware- or software-trigger signals, each corresponding to a specific event, are fed to the system and all devices must be properly coordinated and synchronized, not only to generate & send optical and/or electrical signals/stimulations to the specimen, but also to collect data from the specimen. There is also a need to accurately record the timing (“time-stamping”) of those events and actions, in order to ensure reliable post-acquisition data processing and analysis. Mightex PolyEcho intelligent control module is designed to enable such event-driven experiments. The goal is not only to reliably record the timing of all events using timestamps generated by the same clock inside the PolyEcho device, but also to coordinate different devices in order to properly synchronize signal/ stimulation generation and data collection.