Multi-Wavelength Fiber-Coupled LEDs

Mightex BLS-series BioLED light sources are modularized fully-customizable turn-key solutions for optogenetics, fluorescence excitation, and other biophotonics applications. Precisely-timed and high-intensity light pulses are required in optogenetics experiments to activate channelrhodopsins (ChR2, ChR1 etc.) and halorhodopsins (NpHR) in order to excite and inhibit neurons. To meet these requirements, Mightex has developed a proprietary “IntelliPulsing” technology to allow BLS-series sources to output significantly higher power in pulse mode than what the LEDs are rated for in CW mode.
Mightex BLS-series multi-wavelength fiber-coupled LED light sources employ the latest high-power LED technologies and a proprietary coupling optics to achieve maximum optical output power. Multiple LED’s with different emitting wavelengths are combined into the same fiber output with high efficiency and without using any moving parts in the optical path. In conjunction with BioLED light source control modules, these LED sources are ideal for optogenetics and other bio-photonics applications.

Key features:

• Broad wavelength selections, from 240nm to 940nm
• Multiple wavelengths (i.e. up to 8) combined efficiently into the same optical fiber)
• Interchangeable fiber patchcord ranging from 50um to 100um core diameter.
• No moving parts in the optical path
• LEDs can be turned ON/OFF individually or at the same time
• High output power
• High stability (spatial and temporal)
• Fast switching

Multi-Wavelength Fiber-Coupled LEDs

Note: * – measured with a 400µm core 0.22 numerical aperture (NA) fiber. Output optical power scales approximately linearly with fiber core area and NA. With a 400micron-core 0.39NA fiber, the output power will be up to 3.14x as what has been stated in the table above. 1. IntelliPulsing only available when working with BLS-SA02/04-US BioLED control modules.

Optogenetics Starter Kit

Mightex’s optogenetics starter kits are ready-to-use turn-key solution for ChR2 stimulation, and they feature super-high output power (up to 7.2mW with a 200µm fiber) and ultra-low power variation (<2%) during rotation. The optogenetics starter kit is typically composed of the following items:

(1) A 470nm fiber-coupled LED source (P/N: BLS-FCS-0470-100);
(2) An LED controller module;
(3) A fiber-optic rotary joint with SMA connector on one end and ceramic ferrule on the other, or a fiber-optic patch cord with SMA connector on one end and ceramic ferrule on the other;
(4) Two (2) mating sleeve for ferrule or cannula; and
(5) Four (4) implantable fiber optic cannula (two 5mm in length and two 10mm in length).

Mightex’s optogenetics starter kits can be summarized in the chart below.