Light-sensitive Ca2+ Signaling in the Mammalian Choroid
Research Summary:
This study explored how light regulates blood flow and fluid balance in the eye’s choroid, a highly vascular layer that supports the retina. Alex and his team used ex vivo mouse eye preparations with cell-specific calcium indicators to study choroidal responses to light.
They discovered two light-sensitive mechanisms: one in endothelial cells that boosts nitric oxide production, and another in smooth muscle cells that triggers vasoconstriction. Light was found to increase choroidal endothelial permeability and decrease perfusion, supporting fluid absorption. Interestingly, pressure and blood flow influenced how light affected these cells, indicating a unique, inverted form of autoregulation in the choroid. These findings show how light helps maintain ocular fluid balance and blood flow to support retinal function.
Mightex’s Contribution:
Alexis a P.h.D student at the University of Nevada, Reno, specializing in metabolic and cardiovascular diseases. His pioneering research at the Gonzales lab focused on the active role of capillary networks in sensing and responding to metabolic cues, specifically the dynamic regulation of blood flow within capillaries–tiny yet essential vessels that serve as the lifeline for oxygen and nutrient delivery to tissues. Combining innovative experimental approaches with advanced optics, Alex’s work has removed barriers to discovery, enabling exploration of capillary physiology at an unparalleled level of detail, paving the way for future therapeutic innovations.