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This new application note by Matthew Tran from Blake Richards’s lab at the University of Toronto details a dual magnification setup optimized for the combination of both visually guided whole-cell patch-clamping at high magnification and targeted optogenetic stimulation at low magnification. This application note solves the mismatch between the magnification required for visually guided patch-clamping (40-60x) and the ideal magnification for optical stimulation of specific pathways in a brain slice (≤5x). This setup can be adapted by any researcher who wants to use light-sensitive actuators in their experiments

To read this new application note, please click here.

For more information about research being perform in the Richards’s lab, visit the Learning in Neural Circuits (LiNC) lab website.

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