How it Works: Targeted Optogenetic Control of Microtubule-binding Proteins

Cellular architecture and behaviour is largely dependent on the organization and dynamics of the microtubule cytoskeleton. Coordination of microtubules inside cells are regulated by diverse microtubule-binding proteins, which in turn recruit effector proteins that control microtubule growth. A recently published paper in Nature Cell Biology from Torsten Wittman’s lab at...

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New Application Note! Microscopic Setup for Simultaneous Optogenetics and Electrophysiology.

This new application note by Matthew Tran from Blake Richards's lab at the University of Toronto details a dual magnification setup optimized for the combination of both visually guided whole-cell patch-clamping at high magnification and targeted optogenetic stimulation at low magnification. This application note solves the mismatch between the magnification required...

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Our New White Paper on Optogenetics in Cell Biology!

Optogenetic approaches in cell biology applications are becoming more and more ubiquitous as molecular toolkits expand. However, identifying which pattern illumination technologies to use with them may be challenging. This white paper provides an overview of the molecular probes available to the cell biologist and how they have been applied in...

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