Blog
Congrats to CAN Travel Grant Winners: Kim Gruver & Azam Asgarihafshejani
Congratulations to our CAN 2019 Travel Grant winners Kim Gruver (McGill University) from Dr. Alanna Watt's lab and Azam Asgarihafshejani (Universite de Montreal) from Dr. Jean-Claude Lacaille's Lab. Both Kim and Azam presented their research at CAN 2019 that involved using Mightex's Polygon400. Kim’s (pictured on the left below) research utilizes...
Working memory enables us to both temporarily hold information in our minds for further cognitive processing and direct future behaviour. Previous studies in rodents demonstrate that subsets of neurons in the prefrontal cortex that are active during a cue remain active in the delay period, even in the absence of...
Introducing the Polygon1000 Pattern Illuminator
Mightex is proud to introduce the next generation of Polygon for patterned illumination, the Polygon1000. The Polygon1000 provides the same features and reliability as Mightex’s market-leading Polygon400 (currently used in 300+ labs worldwide and published with in 35+ publications), and improved design for more intricate photostimulation experiments. Key Features: 1. Higher pixel...
How It Works: Grid-Scanning Optogenetic Stimulation to Study Plasticity in Cortical Neurons
The ability to change the strength of connections between neurons, known as synaptic plasticity, has been shown to be extremely important for learning and memory within the brain. One proposed mechanism for how this ability manifests is known as hetereosynaptic plasticity, whereby changes in synaptic strength occurs at a synapse...
Come Visit Mightex at SFN 2018 in San Diego, California (Booth #3130)!
SFN 2018 (November 11-14th) in San Diego, California is approaching fast and Mightex will be attending (booth #3130). Mightex will have live demos of their Polygon400 patterned illuminator for cellular-resolution optogenetic stimulation, as well as their OASIS Implant for freely-behaving cellular-resolution optogenetics and calcium imaging. There will be plenty of interesting...
Congrats to Travel Grant Winner: Matthew Tran from the University of Toronto!
Congratulations to our recent Travel Grant winner Matthew Tran (University of Toronto) from Dr. Blake Richard's lab! Matthew presented his research using the Polygon400 this year at FENS 2018 in Berlin Germany. You can read more about Matthew's work here and how he uses the Polygon400 Pattern...
Asymmetric distribution of determinants is an important mechanism for patterning cells and embryos throughout development. Whether it is the polarized localization of PAR proteins, or RNA and protein granules, the spatial anisotropy of specific molecules within cells can lead to different cell behaviours and cell fate determination. Many biochemical networks...
Congrats to Video/Photo Award Winner: Elliot Dine from Princeton University!
Congratulations to our recent Video/Photo award winner Elliot Dine (Princeton University) from Dr. Jared Toettcher's lab! You can find out more about Elliot's work below and how he uses the Polygon400 Pattern Illuminator in his research. You can read more about this work in their recently published paper in Cell...
How it Works: Targeted Optogenetic Stimulation of Cholingeric Fibers in the Hippocampus
The basal forebrain is the one of the main sites of acetylcholine (ACh) production, projecting to various regions throughout the brain. The cholinergic system has been shown to contribute to important cognitive processes, such as attention and memory. Previous findings suggest that basal forebrain projections form non-synaptic connections...
Mightex developed Trainee Awards to contribute to the scientific community by supporting and acknowledging the work of students performing research that is advancing the fields of neuroscience, cell biology, and many more. Mightex Trainee Awards, such as travel grants, student research awards, and others, are in place to support the...
Come Visit Mightex at FENS 2018 in Berlin, Germany (Booth #142)!
FENS 2018 (July 7-11th) in Berlin, Germany is approaching fast and Mightex will be attending (booth #142). Mightex will have live demos of their Polygon400 patterned illuminator for targeted optogenetic stimulation, as well as their OASIS Implant for freely-behaving targeted optogenetics and calcium imaging. There will be plenty of interesting talks...
How it Works: Targeted Optogenetic Control of Microtubule-binding Proteins
Cellular architecture and behaviour is largely dependent on the organization and dynamics of the microtubule cytoskeleton. Coordination of microtubules inside cells are regulated by diverse microtubule-binding proteins, which in turn recruit effector proteins that control microtubule growth. A recently published paper in Nature Cell Biology from Torsten Wittman’s lab at...
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