Blog
In vivo calcium imaging of somatostatin positive neurons during social interaction tasks
Check out this OASIS Implant customer highlight focused on Huanhuan Li. Huanhuan spoke with Mightex Applications Scientist, Dr Catherine Thomas, about his doctoral work using the OASIS Implant to conduct in vivo Ca2+ imaging of somatostatin-expressing cell activity in the cingulate cortex during social interaction test in freely moving mice.
Examining functional connectivity within the cerebellar microcircuit
We are pleased to share recent work from Kim Gruver, a recipient of the Mightex Annual Research Award, 2021, and Mightex Student Travel Award for presetnign her work at the Canadian Association for Neuroscience (CAN) meeting in Toronto (May, 2022). Kim's doctoral work combines patterned illumination from the Mightex Polygon...
The Mightex Team at Summer Conferences 2022
Our frontline team have been busy connecting with our scientific communities across numerous research fields including behavioural neuroscience, microfluidics, and nanorobotics. The team provided live demonstrations of our Polygon and OASIS Implant systems showcasing their market-leading capabilities to conference attendees. Thank you to all of the conference organizers and attendees...
Investigating Signalling Pathways in Hippocampus-Dependent Memory with the OASIS Implant
We are pleased to share recent work from the first prize recipient of the Mightex Annual Research Award, 2021, Jayant Rai. Jay spoke with Mightex Applications Scientist Dr Catherine Thomas about his doctoral work using the OASIS Implant to investigate intracellular signalling pathways involved in hippocampus-dependent memory.
Mightex Community Conversations: Dr. Sarah Hayes
We are excited to share our first research community conversation! This new series focuses on brief conversations with member of our scientific community about their passions inside and outside of the lab. The first community member we are getting to know is Dr. Sarah Hayes.
Optoelectronic Tweezers Based on Mightex’s Polygon Pattern Illuminator
Optoelectronic tweezers (OET) is a useful optofluidic micromanipulation technology that relies on light-induced dielectrophoresis (DEP) for touch-free, noninvasive actuation of micro-scale objects in physical, chemical and biomedical studies. One key challenge for OET technology is the lack of suitable light source capable of coupling with microscope to provide...
What is CRACM (Channelrhodopsin-2-Assisted Circuit Mapping)?
CRACM, or channelrhodopsin-2(ChR2)-assisted circuit mapping, is an optical method used to dissect large, complex neural circuits with optogenetics (Petreanu et al. 2007). To start, ChR2 is expressed in the neuron population of interest, enabling optogenetic activation of this specific cell-type. While recording from an...
Can Optogenetics be Integrated with Fiber Photometry?
Fiber photometry enables researchers to visualize the activity of neuron populations in a freely-behaving animal using calcium imaging (Kim et al. 2016). By ‘reading out’ neural activity, fiber photometry data can be correlated with cognition and behaviour (e.g., the mouse pushes a lever and a...
Calcium imaging enables neuroscientists to visualize the activity of large neuronal populations using fluorescent activity indicators (Grienberger & Konnerth, 2012). The invention of imaging technologies, such as the optical fiberscope or miniscope, allows for calcium imaging to be performed in freely-behaving animals with single-cell resolution (
What Equipment Do You Need to Perform Fiber Photometry?
Fiber photometry has become a very popular method for in vivo calcium imaging due to its simple data output and system design. You are probably asking, what components are needed to perform fiber photometry? In short, you need two main categories of components to perform...
All-Optical Electrophysiology: Integrating Voltage Imaging and Optogenetics
The invention of optogenetics has enabled scientists to use light to turn cell-type specific neural activity on or off with millisecond-precision to probe neural circuit function (Yizhar et al. 2011). Complementing optogenetics, voltage imaging enables scientists to observe cell-type specific neural circuit activity with cellular-resolution...
What Equipment Do You Need for Voltage Imaging?
If someone were to describe voltage imaging to you, it might sound quite simple. When you dig deeper, you start to appreciate the complexity associated with the biology and equipment to perform voltage imaging. You’re probably asking, what are the necessary components to perform voltage...
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